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KMID : 0619020010100010087
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Hae Hwa Medicine
2001 Volume.10 No. 1 p.87 ~ p.94
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A study on development of cancer and immunity
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Abstract
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Most cancers are thought to originate from a single cell that has undergone a somatic mutation, but the progeny of this cell must undergo further changes, probably requiring several additional mutations, before they become cancerous.
This phenomenon of tumor progression, which usually takes many years, reflects the operation of evolution by mutations and natural selection among somatic cells. The rate of the process is accelerated both by mutagenic agents (tumor initiators) and by certain nonmutagenic agents (tumor promoters). Thus many factors contribute to the development of a given cancer, and since some of these factors are avoidable features of the environment, a large proportion of cancers are in principle preventable.
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